The project was funded by the Research Promotion Foundation and lasted 24 months (2006-2008).

The aim of this research was to evaluate the results of early and preventive use of specific formulation of enteral immunonutrition to serious injury patients who are hospitalized in the Intensive Care Unit (ICU). It was also associated to the parameters of the immune response and outcome of hospitalization, as well as the determination of conditions under which treatment becomes beneficial.

This research involved patients that did not fulfill exclusion criteria (ante mortem situation etc.) and had serious traumatic brain injury that required admission to the Intensive Care Unit. It's worth mentioning that this research was conducted via Prospective Randomized Controlled Trial (PRCT).

The investigation showed that the enteric solution of immunonutrition (based mainly on high content of Arginine) in patients with serious traumatic brain injury, it is beneficial compared to the randomized nutrition, even when the feeding is provided early, par excellence enteric, in sufficient quantities and effectively (according to nutrition indicators).

During research, there was an important contribution of scientific announcements and organization of clinical laboratories, in understanding the pathophysiological mechanisms/immunological changes associated with the outcome of traumatic brain injury, as a result of providing enteric immunonutrition. It was also noted that the active participation of clinical dietitian in the therapeutic team (doctors - nurses - physiotherapists) and the use of nutritional protocols for critically ill patients are necessary elements of a modern and effective therapeutic procedure in modern Intensive Care Unit. In addition, it was held an effective implementation of nutrition protocols for critically ill patients and a parallel process documentation using audit system.

The cooperation network established by having as concessionaire the Intensive Care Unit of Nicosia General Hospital and also as collaborating institutions the Cyprus Dietetic Association, the Research Center of University of Nicosia, Athens Surgery Hospital "Saint Olga" and the ICU of Athens Accident Hospital, while the final users are the Ministry of Health of Cyprus and Cyprus Dietetic Association.